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University of Colorado Professional Research Assistant in Aurora, Colorado


University of Colorado – School of Medicine

SCHOOL/DEPARTMENT : SOM/Biochemistry and Molecular Genetics


POSITION TITLE: Professional Research Assistant


Position number: 00779880

The University of Colorado Denver l Anschutz Medical Campus seeks individuals with demonstrated commitment to creating an inclusive learning and working environment. We value the ability to engage effectively with students, faculty and staff of diverse backgrounds.

The laboratory of Jay Hesselberth seeks a Professiional Research Assistant to develop new single-cell technologies. Our lab is in the Department of Biochemistry and Molecular Genetics and part of the newly formed RNA Bioscience Initiative at the University of Colorado School of Medicine.

We recently developed two new approaches to measure biochemical activities in single cells and to enable molecular tracking of molecules in vivo. These approaches lay the groundwork for new methods and applications.

The Hesselberth lab recently developed two new single-cell approaches to measure biochemical activities in single cells ( ) and to track DNA conjugates through tissues ( We now plan to deploy these methods broadly and also develop companion technologies. A Professional Research Assistant will focus on their development and application and will focus on the following projects:

  • Developing of new single-cell biochemical methods to enable CRISPR and small molecule inhibitor screens

  • Integrating single cell biochemistry data with single cell RNA-seqg

  • Optimizing molecular tracking devices for studying ligand dissemination in tissue

  • Applying these tools to spatial approaches to understand biochemical acitivites and ligand dissemination in situ.

The candidate will also work closely with the RNA Bioscience Initiative to develop new analysis strategies for single cell biochemistry and molecular tracking data.

Supervision Received :

This position will report to Dr. Jay Hesselberth.

Supervision Exercised :

The person in this position will be expected to pass on any training or experience they have that is relevant to their work to other people within the laboratory.

Examples of Work Performed:

Growth and transfection of human cell lines, RNA isolation and purification, RT-PCR, high-throughput library preparation, and laboratory management.

Salary and Benefits:

Salary is commensurate with skills and experience. The University of Colorado offers a full benefits package. Information on University benefits programs, including eligibility, is located at Employee Services ( .

University of Colorado Denver | Anschutz Medical Campus is dedicated to ensuring a safe and secure environment for our faculty, staff, students and visitors. To assist in achieving that goal, we conduct background checks for all new employees prior to their employment.

The Immigration Reform and Control Act requires that verification of employment eligibility be documented for all new employees by the end of the third day of work. Alternative formats of this ad are available upon request for persons with disabilities.

Your total compensation goes beyond the number on your paycheck. The University of Colorado provides generous leave, health plans and retirement contributions that add to your bottom line.

Benefits: .

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Diversity and Equity:

Please click here for information on disability accommodations:

Office of Equity:

The University of Colorado Denver | Anschutz Medical Campus is committed to recruiting and supporting a diverse student body, faculty and administrative staff. The university strives to promote a culture of inclusiveness, respect, communication and understanding. We encourage applications from women, ethnic minorities, persons with disabilities and all veterans. The University of Colorado is committed to diversity and equality in education and employment.


Minimum Requirements :

Bachelors degree in biological science or a related field.

Applicants must meet minimum qualifications at the time of hire.

Preferred Qualifications:

  • Experimental experience with molecular biology and biochemistry.

  • Experience with cell culture

  • Experience with RNA.

Job: Faculty

Primary Location: Aurora

Job Category Faculty


Schedule Full-time

Posting Date Nov 19, 2020

Unposting Date Ongoing

Posting Contact Name Jay Hesselberth


Posting Number 00779880

Req ID: 19600

The University of Colorado does not discriminate on the basis of race, color, national origin, sex, age, pregnancy, disability, creed, religion, sexual orientation, gender identity, gender expression, veteran status, political affiliation, or political philosophy. All qualified individuals are encouraged to apply.